Owen O’Leary’s Restaurant and Pub plans to open its third eatery – a brewpub – at the former Piccadilly Pub on Connector Road, targeting before St. Patrick’s Day.

The move will end a four-year search for a new home for the brewpub that was at the Hampton Inn in Natick, Owen O’Leary’s owner Kevin Gill said Monday night. The Natick location closed in 2008, ending 12 years there, he said.

Gill said he has signed a 20-year lease for the space at 17 Connector Road in Westborough, contingent on the proper permits. A Dec. 11 liquor license public hearing with selectmen is next. A late February-early March opening is eyed, he said.

“For four years, we’ve been scouting for the right property,” Gill said.

“We think that that location will make the lunch very strong. The after work crowd will be very strong at that location also.”

Owen O’Leary’s restaurants are at 50 Turnpike Road, Southborough and 1280 Belmont St., Brockton, on the Easton line.

Owen O’Leary’s would “brew our own beer” in Westborough, Gill said.

“The microbrewery business is still strong,” he said.

The Piccadilly Pub closed in February.

A memo posted on the front door, dated Feb. 6, read in part, “Piccadilly Pub Restaurants have temporarily closed. Currently, a date has not been set for a re-opening.” Restaurant chain owner Elephant & Castle filed for Chapter 11 bankruptcy protection in June 2011.